Synthetic biologists design and engineer organisms for a better and more sustainable future. While the manifold prospects are encouraging, concerns about the uncertain risks of genome editing affect public opinion as well as local regulations. As a consequence, biosafety and associated concepts, such as the Safe-by-design framework and genetic safeguard technologies, have gained notoriety and occupy a central position in the conversation about genetically modified organisms. Yet, as regulatory interest and academic research in genetic safeguard technologies advance, the implementation in (...) industrial biotechnology, a sector that is already employing engineered microorganisms, lags behind. The main goal of this work is to explore the utilization of genetic safeguard technologies for designing biosafety in industrial biotechnology. Based on our results, we posit that biosafety is a case of a changing value, by means of further specification of how to realize biosafety. Our investigation is inspired by the Value Sensitive Design framework, to investigate scientific and technological choices in their appropriate social context. Our findings discuss stakeholder norms for biosafety, reasonings about genetic safeguards, and how these impact the practice of designing for biosafety. We show that tensions between stakeholders occur at the level of norms, and that prior stakeholder alignment is crucial for value specification to happen in practice. Finally, we elaborate in different reasonings about genetic safeguards for biosafety and conclude that, in absence of a common multi-stakeholder effort, the differences in informal biosafety norms and the disparity in biosafety thinking could end up leading to design requirements for compliance instead of for safety. (shrink)

Psychological characteristics of athletes play a key role in sport performance and may moderate and mediate the influence of technical, tactical, and physical abilities athletes show. Different authors have emphasized the special attention such psychological characteristics should receive considering the extent they can influence athletes’ behavior either in training or in competition. This paper is aimed at describing the psychological profiles of two cycling sports: triathlon and road cycling. One hundred and twenty-nine male and female professional and amateur cycling athletes (...) (35.74 years old average age ±12.79; 14.94 average number of years practicing cycling ±11.20) were assessed on different psychological characteristics. For that purpose, the Psychological Characteristics related to the Sport Performance (CPRD) Questionnaire and the Psychological Skills Inventory for Sports (PSIS) was used. Results showed significant differences among triathlon and road cyclists (Stress control = t 116 =-3.711, p = 0.000, d = 0.48 ; Influence of Performance Evaluation = t 115 =-3-115, p = 0.002, d = 0.49; Motivation = t 124 =-5.520, p = 0.000, d = 0.82; Mental Skills = t 119 =-4.985, p = 0.000, d = 1.02). There were no significant differences between men and women though there were differences among pros and amateur athletes. Triathlon professional, compared to amateurs, showed higher scores in all the psychological dimensions assessed (Stress control = t 85 = 3.005, p = 0.003, d = 1.07; Influence of Performance Evaluation = t 83 = 2.858, p = 0.005, 0.77; Motivation = t 91 = 2.721, p = 0.008, d = 0.26; Mental Skills = t 87 = 2.556, p = 0.012, d = 0.77). The results of this descriptive study contribute to establishing a model of optimal psychological profiling applied to the different cycling groups that can be used by sport psychologist, trainers, and coaches in order to promote peak performance of these athletes. (shrink)

El derecho a un medio ambiente sano surge con la aparición de los llamados derechos de tercera generación o derechos de solidaridad. El derecho ambiental se caracteriza por una multiplicidad de principios rectores definidos en variados instrumentos internacionales principalmente en la Declaración de Estocolmo sobre Medio Ambiente Humano, la Carta Mundial de la Naturaleza y la Cumbre de la Tierra o Río 92. Estos principios que concretizan los valores de preservación, conservación y desarrollo sostenible, entre otros, los ubicaremos dentro del (...) contexto constitucional colombiano. ¿Derecho humano de tercera generación o fundamental? Una discusión más de carácter semántico que material. ¿Cómo se ha expresado la jurisprudencia colombiana?.mis conclusiones. (shrink)

Hay muchas más preguntas que respuestas, cuando uno se pone a pensar en los diferentes aspectos de la responsabilidad civil extracontractual en el daño ambiental. La primera dificultad que uno se encuentra entre muchas, es la definición o el concepto de lo que significa el medio ambiente; luego viene otro escollo: ¿Qué debe entenderse por daño ambiental? ¿habrá que conceptualizarlo, desde la ecología, desde la antropología, desde la visión de la economía clásica o desde la visión de la economía ambiental, (...) o recurrir a definiciones de carácter normativas? De lo que sí estoy seguro, es de que cualquier concepto, de entrada, tiene el criterio de la flexibilidad como principio. (shrink)

The objective of this research is to develop accurate forecasting models for chlorophyll-α concentrations at various depths in El Mar Menor, Spain. Chlorophyll-α plays a crucial role in assessing eutrophication in this vulnerable ecosystem. To achieve this objective, various deep learning forecasting techniques, including long short-term memory, bidirectional long short-term memory and gated recurrent uni networks, were utilized. The models were designed to forecast the chlorophyll-α levels with a 2-week prediction horizon. To enhance the models’ accuracy, a sliding window method (...) combined with a blocked cross-validation procedure for time series was also applied to these techniques. Two input strategies were also tested in this approach: using only chlorophyll-α time series and incorporating exogenous variables. The proposed approach significantly improved the accuracy of the predictive models, no matter the forecasting technique employed. Results were remarkable, with |$\overline{\sigma}$| values reaching approximately 0.90 for the 0.5-m depth level and 0.80 for deeper levels. The proposed forecasting models and methodologies have great potential for predicting eutrophication episodes and acting as decision-making tools for environmental agencies. Accurate prediction of eutrophication episodes through these models could allow for proactive measures to be implemented, resulting in improved environmental management and the preservation of the ecosystem. (shrink)

In futsal there are two referees on the playing court and their capacity to respond to physical and physiological demands imposed during the game is essential for the success. The futsal characteristics such as size pitch, referees position and rules of games or type of league could impose specific physical efforts probably. The aim of this study were to analyze the physical demands of eight elite referees from seven matches of Spanish Futsal Cup 2020. The physical activity of each referee (...) during the match was monitored with a Local Positioning System, which was installed on futsal pitch where the matches were played. The data differences were evaluated as Paired-Samples T-Test procedure. The results revealed a similar total distance between halves. The zone 3 distance showed a significative decrease during the match in comparison to the first and second halves. The number of high-intensity acceleration and deceleration decreased in the second half of the match. Therefore, the use of the tracking device to monitoring physical performance provides knowledge of the specific activity profile from futsal referees. This information to can be useful to design more accurate the training programs. (shrink)

This work presents a novel approach to forecast streaming big time series based on nearest similar patterns. This approach combines a clustering algorithm with a classifier and the nearest neighbours algorithm. It presents two separate stages: offline and online. The offline phase is for training and finding the best models for clustering, classification and the nearest neighbours algorithm. The online phase is to predict big time series in real time. In the offline phase, data are divided into clusters and a (...) forecasting model based on the nearest neighbours is trained for each cluster. In addition, a classifier is trained using the cluster assignments previously generated by the clustering algorithm. In the online phase, the classifier predicts the cluster label of an instance, and the proper nearest neighbours model according to the predicted cluster label is applied to obtain the final prediction using the similar patterns. The algorithm is able to be updated incrementally for online learning from data streams. Results are reported using electricity consumption with a granularity of |$10$| minutes for 4-hour-ahead forecasting and compared with well-known online benchmark learners, showing a remarkable improvement in prediction accuracy. (shrink)

Gregory Bateson is well known for defining information by stating “In fact what we mean by information – the elementary unit of information – is a difference which makes a difference…” This conceptual perspective has the merit of simplicity and generality. Simplicity, in addressing the complexity of information. Generality, in seeking applicability to any and every field of human experience. The purpose of this paper is to focus the applicability of this conceptual approach by Bateson and use it to perform (...) a calculation of taking the difference between two grey-level digital images that are shifted one relative to the other. The digital images take the place of the field of view that a human being would have access through her sense of vision at two different spatial/temporal instances. The results show that it is possible to highlight the edges of the objects under scrutiny, as well as to highlight other differences within the object. Bateson’s “difference that makes a difference” would seem to provide a first step in the elusive meaning making process of humans. (shrink)

En los cursos dictados en el Collège de France a partir de 1978 Michel Foucault propuso una analítica de las formas de gobierno, que aunque no estaba completamente ausente de sus trabajos anteriores, si se veía opacada por el protagonismo dado a los análisis disciplinarios. Esta analítica de las formas de gobierno consiste en mostrar cómo se construyen estrategias y racionalidades de gobierno a partir de la gestión y modulación de los procesos innatos a los individuos y los grupos gobernados. (...) Ya no se trata de entender el poder como una fuerza externa que se opone a los individuos y que opera reprimiéndolos o suprimiéndolos, sino como una estrategia que opera promoviendo procesos naturales a partir de los cuales los sujetos constituyen su identidad. (shrink)

The generation of the pitch control signal in a wind turbine (WT) is not straightforward due to the nonlinear dynamics of the system and the coupling of its internal variables; in addition, they are subjected to the uncertainty that comes from the random nature of the wind. Fuzzy logic has proved useful in applications with changing system parameters or where uncertainty is relevant as in this one, but the tuning of the fuzzy logic controller (FLC) parameters is neither straightforward nor (...) an easy task. On the other hand, reinforcement learning (RL) allows systems to automatically learn, and this capability can be exploited to tune the FLC. In this work, a WT pitch control architecture that uses RL to tune the membership functions and scale the output of a fuzzy controller is proposed. The RL strategy calculates the fuzzy controller gains in order to reduce the output power error of the WT according to the wind speed. Different reward mechanisms based on the output power error have been considered. Simulation results with different wind profiles show that this architecture performs better (123.7 W) in terms of power errors than an FLC without RL (133.2 W) or a simpler PID (208.8 W). Even more, it provides a smooth response and outperforms other hybrid controllers such as RL-PID and radial basis function neural network control. (shrink)

Uno de los aspectos dominantes en los desarrollos de las ciencias sociales y las humanidades en la actualidad es la adaptación de enfoques naturalistas. Los programas naturalistas rechazan el estatuto de lo humano que había defendido tradicionalmente la filosofía al sostener que la conciencia es reducible a un hecho contingente y, por lo tanto, puede comprenderse desde un criterio meramente objetivista. El filósofo francés Jean-Marie Schaeffer llama a esta postura la “tesis de la excepción humana” y sostiene que la fenomenología (...) de Edmund Husserl es el último ejemplo de esta postura. Trataremos de mostrar que el antinaturalismo tan característico de la fenomenología husserliana es sostenible pese a la crítica de Schaeffer. En este sentido, buscamos explorar brevemente la posibilidad y sentido de una fenomenología naturalizada.One of the key aspects in the development of the social sciences and humanities today is the adaptation of naturalistic approaches. Naturalists programs reject the status of the human that had traditionally defended philosophy holding that consciousness is reducible to a contingent fact and, therefore, can be understood from a purely objectivist approach. The French philosopher Jean-Marie Schaeffer calls this approach the “thesis of human exception” and argues that the phenomenology of Edmund Husserl is the latest example of this approach. Try to show that the anti-naturalism so characteristic of Husserlian phenomenology is sustainable despite criticism of Schaeffer. Here, looking briefly to explore the possibility and way of a naturalized phenomenology. (shrink)

Resumen: En la primera parte del presente artículo se estudia la naturaleza de los denominados culturemas, entendidos como unidades semióticas cuyo referente es un elemento perteneciente a una cultura dada desconocido o sin equivalente exacto en otras culturas y que, por tanto, es percibida como una especificidad cultural. Igualmente, se analizan los criterios tanto para su clasificación tradicional por contenido referencial como su clasificación por relevancia semiótica en una traducción. En la segunda parte se aplica el método culturo-traductológico para analizar (...) culturemas presentes en la obra de Iván Turguéniev, Rudin, y la forma de transponerlos en las diferentes versiones al español existentes por parte de distintos traductores.: In the first part of this article, the nature of so-called culturemes is studied, understood as semiotic units referring to an element belonging to a given culture which is unknown or without an exact equivalent in other cultures, and which is therefore perceived as a cultural specificity. Additionally, criteria are examined for both their traditional classification by referential content, and their classification by semiotic relevance in a translation. In the second part, the cultural-traductological method is used to analyse culturemes present in Rudin, the work by Iván Turguéniev, and the way of transposing these in the different Spanish versions by different translators. (shrink)

The aim of this study was to evaluate the neuromuscular response to an agility and repeated sprint ability test according to the level of competition in futsal players. A total of 33 players from two elite teams and one amateur team participated in the study. The participants completed an agility t-test, a 30 m-speed test, and a RSA test. A countermovement jump test and a tensiomyography test of the rectus femoris and biceps femoris of both legs were carried out before (...) and after the tests. RSA test revealed better sprint times in elite players compared to amateurs in the seven bouts, as well as in the 30 m sprint and in the agility test. In conclusion, elite players showed greater performance in the RSA test, in the 30 m tests and in the agility test compared to amateur players. The contractile properties were not a key factor in the RSA performance of the futsal players. (shrink)

Este ensayo analiza el problema de la alteridad desde la perspectiva que lafenomenología husserliana ofrece. Tomando como hilo conductor los conceptos de “experiencia de lo extraño” y “analogía,” se considera que la conquista de América es un excelente ejemplo de la pertinencia de esta manera de entender la alteridad cultural.This paper analyzes the problem of the alterity from the perspective that theHusserlian phenomenology offers. Taking as a thread the concepts of “experience of the strange” and “analogy”, the conquest of America (...) is thought to be an excellent example of the appropriateness of this way of understanding the cultural alterity. (shrink)

El presente artículo plantea, partiendo de las vivencias de padres oyentes ante la llegada de un hijo sordo a partir de sus narraciones y experiencias de vida, por un lado, la comprensión de las etapas por las que atraviesan desde el momento en que se sospecha la existencia de la discapacidad de su hijo, hasta el momento en que es confirmada y asumida; por otro lado, describir los cambios que se producen al interior de la dinámica familiar ante la llegada (...) de un hijo en situación de discapacidad auditiva. (shrink)

Automated Guided Vehicles (AGV) are an essential element of transport in industry 4.0. Although they may seem simple systems in terms of their kinematics, their dynamics is very complex, and it requires robust and efficient controllers for their routes in the workspaces. In this paper, we present the design and implementation of an intelligent controller of a hybrid AGV based on fuzzy logic. In addition, genetic algorithms have been used to optimize the speed control strategy, aiming at improving efficiency and (...) saving energy. The control architecture includes a fuzzy controller for trajectory tracking that has been enhanced with genetic algorithms. The cost function first maximizes the time in the circuit and then minimizes the guiding error. It has been validated on the mathematical model of a commercial hybrid AGV that merges tricycle and differential robot components. This model not only considers the kinematics and dynamics equations of the vehicle but also the impact of friction. The performance of the intelligent control strategy is compared with an optimized PID controller. Four paths were simulated to test the approach validity. (shrink)

RESUMEN El presente trabajo está dirigido a exponer elementos inherentes al modelo de superación profesional del tecnólogo de la salud en laboratorio clínico desde la integración ciencias básicas biomédicas-laboratorio. Entre los métodos teóricos empleados, el analítico-sintético permitió la determinación de los fundamentos epistemológicos y praxiológicos del proceso de superación, el inductivo-deductivo posibilitó la determinación de las categorías que surgen en el proceso investigativo, el sistémico estructural funcional para fundamentar el carácter de sistema del modelo y la modelación con la finalidad (...) de construirlo. Se concluye que se establecen como subsistemas del modelo, la proyección profesional de las ciencias básicas biomédicas, la contextualización profesional de la integración ciencias básicas biomédicas-laboratorio y la valoración contextual de la integración en el proceso de superación, lo que explica el proceso de superación del tecnólogo de la salud en laboratorio clínico. ABSTRACT This paper aims at setting out elements inherent to the health technologist in clinical laboratory’s professional training model from the integration of basic biomedical-laboratory sciences. Among the theoretical methods used, analysis-synthesis allowed establishing the epistemological and praxeological basis of the training process; the inductive-deductive method made it possible to determine the categories that result from the research process and the systemic-structural-functional method was used to support the system-like nature of the model and modelling with the end of building it. In conclusion, subsystems of the model are established: basic biomedical sciences professionals’ aims, professional conceptualization of the integration of basic biomedical-laboratory sciences and the contextual assessment of integration in the training process, which expounds the training process of the health technologist in clinical laboratory. (shrink)

RESUMEN El presente artículo está dirigido a sistematizar una concepción teórica y metodológica que sustente el proceso de extensión universitaria en la carrera de Medicina en Cuba. Entre los resultados se destaca el lugar y papel de la extensión universitaria en el sistema de la formación integral del profesional a la que se asigna una connotación especial, de marcado contenido axiológico, coherente con las necesidades y proyecciones sociales que facilita la formación del educando y fortalece la relación institución-comunidad. Es factible (...) de ser aplicado pues puede devenir en una importante contribución a elevar el impacto social de la docencia médica en tanto atiendan aspectos como la preparación de los implicados en las diferentes instancias; la colaboración de los consejos populares y los factores de la comunidad que se manifiestan en el modo de actuación del profesional. ABSTRACT The present article is directed to systematize a theoretical and methodological conception that sustains the process of university extension in the career of Cuban medicine. Among the results he/she stands out the place and paper of the university extension in the system of the integral formation from the professional to which a special connotation is assigned, of marked axiological contained, coherent with the necessities and social projections that it facilitates the formation of the educating and it strengthens the relationship institution-community. It is feasible of being applied then it can become in an important contribution to elevate the social impact of the medical teaching as long as they assist aspects like the preparation of those implied in the different instances; the collaboration of the popular advice and the factors of the community that are manifested in the way of the professional's performance. (shrink)

La relevancia del pensamiento de Emmanuel Levinas para comprender el surgimiento de la filosofía de la liberación –uno de los movimientos filosóficos más importantes de América Latina durante la segunda mitad del siglo XX– es innegable. En este artículo se analiza la interpretación geopolítica y analógica que Enrique Dussel realizó de los conceptos levinasianos de “Alteridad” y “Otro” para mostrar su equivocidad en el ámbito de lo político.

La filosofía judía contemporánea, particularmente la surgida de la historia herida del pensador lituano Emmanuel Levinas, presenta de modo exclusivista la reducción de la relación religiosa a relación ética. No sólo queda ahí su propuesta sino que este filó-sofo judío considera la experiencia mística una degeneración o peligro para la religiosidad auténtica. En cambio, el mayor especialista español en los estudios de fenomenología de la religión, el pensador cristiano Juan Martín Velasco, considera la experiencia mística como la culminación de la (...) experiencia religiosa. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

En el centenario del nacimiento del historiador francés se analiza su influencia, y la presencia de su obra en el ámbito hispánico.

Firm managers play an important role in the implementation of corporate social responsibility (CSR) actions. Education is emerging as the key factor in developing a sense of moral responsibility amongst the business students who will eventually become company managers and decision makers. The aim of this research is, thus, twofold. First, to analyze the existence of a direct positive correlation between university students’ perception of CSR and its impact on business performance; and second, to examine the extent to which two (...) factors (advantages brought by CSR and responsibilities toward stakeholders) act as mediation variables in the aforementioned correlation. The analysis was performed with a sample of 390 business‐related university students. Amongst the potential contributions made by this study we can highlight the possibility of knowing future managers’ way of thinking and of knowing the aspects where educational centers might improve their CSR teaching. (shrink)

Este artículo aborda la violencia como problema filosófico desde dos enfoques de pensamiento ubicados en latitudes geo-históricas distintas. En primer lugar, se presenta a la Escuela de Frankfurt, a través de la obra Dialéctica de la ilustración (1944/1947). En segundo lugar, desde América Latina se expone la Filosofía de la Liberación, a la luz de Enrique Dussel en los planteamientos de su obra El encubrimiento del otro: el origen del mito de la modernidad (1994). Ambos discursos articulan un análisis (...) crítico del fenómeno de la violencia, diagnosticando los síntomas degradados del proyecto civilizatorio de la Modernidad. (shrink)